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The Los Angeles Chargers and Kansas City Chiefs battle in Week 15 of the 2025 NFL season with Kansas City's playoff hopes hanging in the balance while the Chargers remain in contention for the AFC West division title. These teams met in Week 1 in Brazil, with the Chargers registering a statement win with a 27-21 result.

Kickoff from Arrowhead Stadium is set for 1 p.m. ET on CBS and Paramount+. The Chiefs are 5.5-point favorites in the latest Chargers vs. Chiefs odds at DraftKings, while the over/under is set at 41.5. Before making any Chiefs vs. Chargers picks of your own, make sure to look at the top NFL picks from the SportsLine Projection Model, which simulates every NFL game 10,000 times. 

Where to watch Chargers vs. Chiefs on Sunday

When: Sunday, Dec. 14
Time: 1 p.m. ET
TV: CBS
Stream: Paramount+  
Follow along: CBS Sports App

Chargers vs. Chiefs betting preview

Odds: Chiefs -5.5, over/under 41.5

The Chiefs are 5-7-1 against the spread on the season but 0-5 ATS in their last five games. The Chargers are also 6-6-1 ATS but are 2-0 ATS as underdogs. Los Angeles is 5-1 straight up in its last six games but is only 1-7 straight up in its last eight games against Kansas City. The total has gone Under in seven of Kansas City's last eight games and in four of the last five Chargers vs. Chiefs games.

Chargers vs. Chiefs SGP

  • Chiefs -5.5
  • Under 41.5
  • Omarion Hampton anytime touchdown (+145)

Bet it at DraftKings:

Model's Chargers vs. Chiefs score prediction, picks

The SportsLine Projection Model has the Chiefs covering at home in 55% of simulations, but it does see value on the Chargers as plus money underdogs with Los Angeles winning in 32% of simulations. Even though most of these games have gone Under of late, the model has the Over (41.5) hitting in 52% of simulations.

Chargers vs. Chiefs score prediction: Chiefs 25, Chargers 18

Want more Week 15 NFL picks?

You've seen the model's best bets for Los Angeles Chargers vs. Kansas City Chiefs. Now, get against the spread, total and money-line picks for every Week 15 NFL game here, all from the model that's simulated every game 10,000 times.